Koichiro Tsuchiya Selected Research

Camptothecin

1/2020

Novel Hydrophilic Camptothecin Derivatives Conjugated to Branched Glycerol Trimer Suppress Tumor Growth without Causing Diarrhea in Murine Xenograft Models of Human Lung Cancer.

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Koichiro Tsuchiya Research Topics

Disease

13	Cardiovascular Diseases (Cardiovascular Disease) 12/2019 - 05/2002
11	Neoplasms (Cancer) 10/2023 - 06/2005
11	Hypoxia (Hypoxemia) 10/2023 - 12/2009
10	Hypertension (High Blood Pressure) 12/2019 - 08/2003
8	Ischemia 11/2015 - 03/2002
8	Atherosclerosis 07/2010 - 01/2003
6	Inflammation (Inflammations) 09/2023 - 01/2012
5	Fibrosis (Cirrhosis) 09/2023 - 01/2014
5	Hypertrophy 01/2022 - 05/2002
5	Obesity 01/2022 - 11/2011
5	Vascular Remodeling 12/2019 - 08/2004
4	Chronic Renal Insufficiency 09/2023 - 08/2009
4	Proteinuria 01/2014 - 03/2006
4	Reperfusion Injury 07/2008 - 03/2002
3	Hepatocellular Carcinoma (Hepatoma) 02/2024 - 01/2012
3	Insulin Resistance 01/2022 - 08/2005
3	Anemia 01/2020 - 01/2017
3	Body Weight (Weight, Body) 01/2018 - 02/2010
3	Type 2 Diabetes Mellitus (MODY) 01/2015 - 11/2011
2	Pancreatic Neoplasms (Pancreatic Cancer) 12/2023 - 02/2010
2	Heart Failure 09/2023 - 01/2023
2	Acute Kidney Injury (Acute Renal Failure) 09/2023 - 01/2021
2	Ureteral Obstruction 05/2023 - 01/2014
2	Heart Arrest (Cardiac Arrest) 01/2019 - 12/2017
2	Atrophy 01/2019 - 05/2016
2	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2018 - 08/2009
2	Parkinson Disease (Parkinson's Disease) 01/2018 - 01/2006
2	Diabetic Nephropathies (Diabetic Nephropathy) 01/2014 - 04/2013
2	Glomerulonephritis 02/2010 - 03/2006
2	Myocardial Ischemia (Ischemic Heart Diseases) 07/2008 - 04/2008
2	Infarction (Infarctions) 07/2008 - 04/2008
1	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2024
1	Irritable Bowel Syndrome (Syndrome, Irritable Bowel) 01/2024
1	Edema (Dropsy) 09/2023
1	Hypertriglyceridemia 05/2023

Drug/Important Bio-Agent (IBA)

12	Angiotensin IIIBA 12/2019 - 05/2002
11	IronIBA 01/2022 - 01/2012
6	NG-Nitroarginine Methyl Ester (L-NAME)IBA 02/2010 - 08/2003
6	NitritesIBA 02/2010 - 12/2004
5	Glucose (Dextrose)FDA LinkGeneric 01/2020 - 11/2011
5	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2017 - 03/2002
5	MitogensIBA 02/2010 - 05/2002
4	AntioxidantsIBA 01/2018 - 08/2004
4	nitrosonifedipineIBA 01/2018 - 01/2013
4	Phosphotransferases (Kinase)IBA 04/2015 - 05/2002
4	Proteins (Proteins, Gene)FDA Link 01/2015 - 05/2002
4	QuercetinIBA 01/2011 - 05/2002
4	FlavonoidsIBA 01/2011 - 05/2002
3	Hemoglobins (Hemoglobin)IBA 05/2023 - 11/2008
3	Cisplatin (Platino)FDA LinkGeneric 08/2022 - 01/2021
3	Superoxides (Superoxide)IBA 01/2019 - 01/2011
3	Messenger RNA (mRNA)IBA 01/2018 - 01/2015
3	CytokinesIBA 01/2012 - 03/2003
3	Insulin (Novolin)FDA Link 11/2011 - 08/2005
3	NitratesIBA 02/2010 - 12/2004
3	glycosylated-nitric oxide complex hemoglobin AIBA 05/2006 - 08/2003
2	ProdrugsIBA 10/2023 - 05/2012
2	Fibric Acids (Fibrates)IBA 05/2023 - 10/2012
2	Glycerol (Glycerine)FDA LinkGeneric 01/2020 - 01/2012
2	Ligases (Synthetase)IBA 01/2019 - 05/2016
2	AminopropionitrileIBA 01/2019 - 01/2018
2	UbiquitinIBA 01/2019 - 05/2016
2	Ferritins (Ferritin)IBA 01/2018 - 08/2015
2	Dopamine (Intropin)FDA LinkGeneric 01/2018 - 01/2006
2	Blood Glucose (Blood Sugar)IBA 01/2018 - 01/2012
2	Oxygen (Dioxygen)IBA 04/2015 - 01/2015
2	Glucagon-Like Peptide 1 (GLP 1)IBA 01/2015 - 01/2014
2	Dietary IronIBA 01/2015 - 04/2013
2	Free RadicalsIBA 10/2014 - 01/2011
2	Deferoxamine (Desferal)FDA LinkGeneric 01/2014 - 01/2012
2	Antihypertensive Agents (Antihypertensives)IBA 01/2011 - 02/2009
2	Transcription Factor AP-1 (Transcription Factor AP 1)IBA 01/2011 - 05/2002
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 02/2010 - 01/2005
2	dinitrosyl iron complexIBA 02/2010 - 11/2008
2	olmesartanIBA 02/2010 - 05/2006
2	Acetylcysteine (Siran)FDA LinkGeneric 04/2008 - 08/2004
2	N- (2- chloro- 5- methoxyphenyl)- 6- methoxy- 7- ((1- methyl- 4- piperidinyl) methoxy) 4-quinazolinamineIBA 09/2006 - 06/2005
2	src-Family KinasesIBA 09/2006 - 06/2005
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 09/2006 - 06/2005
2	anilinoquinazolineIBA 09/2006 - 06/2005
2	Probucol (Lorelco)FDA Link 03/2006 - 08/2004
2	ebselenIBA 02/2004 - 01/2004
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2004 - 03/2003
1	erastinIBA 02/2024
1	SesquiterpenesIBA 02/2024
1	Small Interfering RNA (siRNA)IBA 12/2023
1	Fluorouracil (Carac)FDA LinkGeneric 12/2023
1	U-104IBA 12/2023
1	azomycinIBA 10/2023
1	gorei-sanIBA 09/2023
1	oryeongsanIBA 09/2023
1	DiureticsIBA 09/2023
1	Folic Acid (Vitamin M)FDA LinkGeneric 09/2023
1	Adenine FDA LinkGeneric 05/2023
1	Urea (Carbamide)FDA LinkGeneric 05/2023
1	CreatinineIBA 05/2023

Therapy/Procedure

4	Oral Administration 01/2012 - 08/2003
3	Drug Therapy (Chemotherapy) 01/2024 - 06/2014
2	Lasers (Laser) 11/2015 - 10/2012
1	Kampo Medicine (Kampo) 09/2023